THINPREP PAP TEST

A robust body of evidence in multiple medical journals show the ThinPrep Pap test has improved specimen adequacy and cervical disease detection versus conventional Pap testing.48

Clinician versatility

The ThinPrep Pap test was the first liquid-based Pap test FDA-approved/cleared for HPV, chlamydia/gonorrhea and trichomoniasis testing out of the same vial.

Aptima® HPV assay, Aptima® HPV 16 18/45 Genotype assay, Aptima Combo 2® assay for CT/NG, Aptima® Trichomonas vaginalis assay, Cervista® HPV HR assay, Cervista® HPV 16/18 assay, cobas® HPV assay, cobas® 4800 CT/NG Test, digene® HC2 HPV DNA Test, ProbeTec™ CT/GC Qx Amplified DNA assays

FDA approval/clearance gives you the confidence in test results without having to self-validate tests.

Since the ThinPrep Pap test was approved by the FDA in 1996, more than 170 studies have demonstrated its benefits, including increased disease detection, reduction of equivocal diagnoses, improved specimen adequacy, adjunctive molecular testing and morphology assessment.48 These published, peer-reviewed studies involving hundreds of thousands of patients show a significant benefit in the ThinPrep Pap test compared to a conventional pap smear.48 These studies, conducted in 7 different countries over 4 continents, also consistently demonstrate improved specimen adequacy.48 Additionally, the ThinPrep Imaging system has been shown to provide further improvements in disease detection along with decreased false negative rates compared to manually reviewed ThinPrep Pap test slides.49*

The weight of the evidence

Specimen collection is a key factor in obtaining adequate and representative samples for analysis. Therefore, when collecting specimens, it is important to use appropriate devices and techniques, such as avoiding the use of lubricants.* The ThinPrep Pap test’s standard preparation method for specimen collection has been used by physicians for over 10 years for a variety of cytologic specimens.50

*The use of lubricants should be avoided prior to specimen collection.Lubricants can adhere to the filter membrane and may cause poor cell transfer to the slide. If its use is unavoidable, the lubricant should be used in minimum amounts, a carbomer- free lubricant is recommended. Please consult with your Hologic sales representative for a list of the preferred brands.
Chain of custody verification using ThinPrep 5000
Sample integrity preservation
Patient comfort

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thinprep 2000
processor

This lightweight benchtop with a compact footprint has a track record of more than 20 years of laboratory success. Thousands of ThinPrep processors are in use worldwide.47 This versatile processor is lightweight and multiple units can be easily operated by a single operator. It is compatible with ThinPrep Pap test, ThinPrep Non-Gyn and ThinPrep UroCyte samples. The processor is simple and easy to use, with minimal consumables needed and an intuitive design to enable single sample processing, thus reducing the risk of chain-of-custody errors.

ThinPrep 3000 Processor IFUs and Operator’s Manuals may also be accessed via the IFU and Operator’s Manuals links above.

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Capacity of samples:
Up to 20
Capacity of consumables:
Up to 20 slides and filters
Consumable Loading:
Manual with each run
Slide removal:
After each run
Chain of custody:
Vial/slide match
Walkaway time:
45 min per run

thinprep 5000
processor

The ThinPrep 5000 processor provides continuous hands-free processing of ThinPrep Pap test, ThinPrep Non-Gyn and ThinPrep UroCyte samples with up to 45 minutes of walkaway time leaving operators free to focus on other tasks.51 With improved chain-of-custody verification and automatic vial uncapping, the ThinPrep 5000 processor represents the next generation of slide preparation.51


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Capacity of samples:
Up to 160
Capacity of consumables:
Up to 300 slides and filters
Consumable Loading:
Continuous
Slide removal:
Continuous
Chain of custody:
Slide Etching
Walkaway time:
8 hours

thinprep 5000 autoloader
system

The ThinPrep 5000 Autoloader system maximizes laboratory efficiency while offering even more walkaway freedom with up to 8 hours of hands-free processing of ThinPrep Pap test, ThinPrep Non-Gyn and ThinPrep UroCyte samples.52 The ThinPrep 5000 Autoloader system, with continuous access along with chain-of-custody verification, laser etching and automatic vial uncapping, brings a new dimension of productivity to your cytology workflow.52


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ThinPrep Integrated Imager logo
ThinPrep Integrated Imager

ThinPrep Integrated Imager

The ThinPrep Integrated Imager, Hologic’s newest Pap test imaging solution, combines state-of-the-art imaging technology with the convenience of dual slide review in a single, automated, stand-alone microscope that fits neatly on a desktop.

With the ThinPrep Integrated Imager, individual slides can be imaged and ready for cytotechnologist review in approximately 90 seconds. During that time, the device scans each cell and cell cluster using optical density analysis and proprietary interpretation algorithms across the entire slide. It then identifies 22 fields of interest for the cytotechnologist to determine if further review is needed. Slide reviews are tracked on an intuitive touchscreen. The ThinPrep Integrated Imager tracks each slide’s progress to ensure that abnormal cells and fields of interest are properly presented and reviewed. Areas of concern identified during the review can be electronically marked for further analysis. At any point in the process, users have the ability to review a specific field of interest, manually scan the surrounding area and return to the field of interest to complete the review. If the cytotechnologist determines no additional analysis is needed, slides can be quickly and easily signed out as negative, right then and there.


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ThinPrep Imaging
System and
Review Scope

The ThinPrep Imaging system represents a significant advance in diagnostic capability, with 2 unique components for comprehensive and accurate cervical cancer testing. The ThinPrep Imaging system has been shown to provide increased sensitivity and specificity over manually reviewed ThinPrep Pap test slides.53 In 1 study, the ThinPrep Imaging System was found to have a 50% reduction in false negative fraction when compared to manually reviewed ThinPrep Pap test slides.54

As cells progress from normal to abnormal, their nuclei become progressively larger and darker. Imaging identifies 22 areas of interest within the slide and directs cytotechnologists to examine them.55 This allows for increased sensitivity and specificity over manually reviewed ThinPrep Pap test slides, reduced false negatives and improved standardization at each stage of sample processing.49


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ThinPrep Non-Gyn

ThinPrep Non-Gyn has been used in laboratories around the world for more than 15 years.47 It offers a standardized specimen preparation method for a variety of cytologic specimens.47 The slides are easy to screen and interpret on a clear background with excellent cellular presentation.47 ThinPrep Non-Gyn offers a single, well-preserved slide per case and decreased screening time per slide, which can enable your laboratory to take on new business and continue to grow.

Fine needle aspiration
Mucoid samples
UroCyte

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Cellient
Automated Cell
Block System

The Cellient Automated Cell Block System is the only fully automated cell block system. With overall processing time of less than an hour, vacuum-assisted filtration rapidly concentrates available cells within the block. The system consistently produces diagnostically useful, high quality blocks for efficient review.

Improved capture
over manual cell block
Improved presentation
over manual cell block
Improved consistency
over manual cell block

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Compass Stainer Logo
Compass Stainer Hero Image

Compass Stainer

The Compass Stainer provides low cost affordability to customers who desire automated staining but don’t have the lab space for a larger, more expensive stainer.  The Compass Stainer can store up to 15 staining protocols or programs. Protocol 1 is pre-loaded with the ThinPrep Stain Protocol for customer convenience.  With a smaller footprint, the Compass Stainer is perfect for low volume imaging labs using the Integrated Imager, or for labs that want a dedicated Non-Gyn stainer.  The Compass Stainer offers versatility and is an economical solution for a variety of cytology staining needs.


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